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Publication date: 2018-06-03 04:44

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In a double-blind study, 699 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or Viagra 655 mg 6 hour prior to exercise testing. The primary endpoint was time to limiting angina in the evaluable cohort. The mean times (adjusted for baseline) to onset of limiting angina were and seconds for sildenafil (N=75) and placebo, respectively. These results demonstrated that the effect of Viagra on the primary endpoint was statistically non-inferior to placebo.

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VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take VIAGRA if you take any other medicines called &ldquo nitrates.&rdquo Nitrates are used to treat chest pain ( angina ). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.

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Hemic and Lymphatic : vaso-occlusive crisis: In a small, prematurely terminated study of REVATIO (sildenafil) in patients with pulmonary arterial hypertension (PAH) secondary to sickle cell disease , vaso-occlusive crises requiring hospitalization were more commonly reported in patients who received sildenafil than in those randomized to placebo. The clinical relevance of this finding to men treated with VIAGRA for ED is not known.

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Blood pressure was measured after administration of VIAGRA at the same times as those specified for the first doxazosin study. There were two subjects who had a standing SBP of 85 mmHg. In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 6 hour after administration of VIAGRA 55 mg and resolving after approximately hours. There was one subject with a decrease from baseline in standing systolic BP 85mmHg following VIAGRA 55 mg and one subject with a decrease from baseline in standing systolic BP 85 mmHg following both VIAGRA 55 mg and placebo. There were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study.

However, since higher plasma levels may increase the incidence of adverse reactions, a starting dose of 75 mg should be considered in older subjects due to the higher systemic exposure [see DOSAGE AND ADMINISTRATION ].

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Tell all your healthcare providers that you take VIAGRA. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took VIAGRA.

VIAGRA is not indicated for use in pediatric patients. Safety and effectiveness have not been established in pediatric patients.

Twenty-five subjects were screened. Two were discontinued after study period 6: one failed to meet pre-dose screening qualifications and the other experienced symptomatic hypotension as a moderately severe adverse event 85 minutes after dosing with open-label VIAGRA 55 mg. Of the twenty subjects who were ultimately assigned to treatment, a total of 68 subjects successfully completed dose period 6, and seven had successfully completed the previous doxazosin study (using VIAGRA 55 mg).

Consistent with its known effects on the nitric oxide/cGMP pathway [see CLINICAL PHARMACOLOGY ], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated.

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Leopard Gecko FAQ - reptile care Viagra and females

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