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Publication date: 2018-06-09 04:44

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The most commonly reported adverse reactions in patients taking CIALIS for the treatment of erectile dysfunction or benign prostatic hyperplasia were headache, dyspepsia, back pain and myalgia, in which the incidences increase with increasing dose of CIALIS. The adverse reactions reported were transient, and generally mild or moderate. The majority of headaches reported with CIALIS once-a-day dosing are experienced within the first 65 to 85 days of starting treatment.

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Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

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Rarely, sudden decreased vision , including permanent blindness, in one or both eyes (NAION) may occur. If this serious problem occurs, stop taking tadalafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease , diabetes , high cholesterol , certain other eye problems ("crowded disk"), high blood pressure , if you are over 55, or if you smoke.

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There are limited data from the use of tadalafil in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy , embryonal/foetal development, parturition or postnatal development (see section ). As a precautionary measure, it is preferable to avoid the use of CIALIS during pregnancy.

Η επόμενη εβδομάδα θα είναι ιδιαίτερα κρίσιμη για το μέλλον του Ραφίνια, αφού Μπαρσελόνα και Ίντερ θα καθίσουν στο τραπέζι των διαπραγματεύσεων για τη μεταγραφή του Βραζιλιάνου άσου, ο οποίος προέρχεται από ένα εξάμηνο επιτυχημένου δανεισμού στους Μιλανέζους. Η είδηση επιβεβαιώθηκε και από τον πατέρα του παίκτη, Μαζίνιο, που έκανε δηλώσεις στην ιστοσελίδα «».

Once-a-day dosing both for the treatment of erectile dysfunction and benign prostatic hyperplasia has not been evaluated in patients with hepatic impairment therefore, if prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician (see sections and ).

Tadalafil is predominantly metabolised by the cytochrome P955 (CYP) 8A9 isoform. The major circulating metabolite is the methylcatechol glucuronide. This metabolite is at least 68,555-fold less potent than tadalafil for PDE5. Consequently, it is not expected to be clinically active at observed metabolite concentrations.

Serious cardiovascular events, including myocardial infarction, sudden cardiac death, unstable angina pectoris, ventricular arrhythmia, stroke, transient ischaemic attacks, chest pain, palpitations and tachycardia, have been reported either post marketing and/or in clinical trials. Most of the patients in whom these events have been reported had pre-existing cardiovascular risk factors. However, it is not possible to definitively determine whether these events are related directly to these risk factors, to CIALIS, to sexual activity, or to a combination of these or other factors.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

It is not known whether tadalafil passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

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